Clinical Study

Gain expert insights into the science behind sustainable weight management, mobility, and healthy aging through this exclusive educational webinar featuring researchers and clinicians from the landmark TOPS Study — a groundbreaking $17.1 million international clinical trial focused on women over 50.

As seen in:

SystemLS is supporting research within the TOPS Study, a transcontinental clinical trial focused on weight loss, movement, metabolism, and osteoarthritis prevention in women.

Watch the Full Expert Discussion

In this panel discussion, world-leading researchers and study interventionists explore what the latest evidence is showing about weight loss, mobility, joint health, and the daily behaviours that help people stay consistent.

Who is most at risk of osteoarthritis — and why
How weight loss and exercise may reduce joint stress
Why movement does not have to make joint pain worse
How small daily habits support long-term results
Real-world insights from participants inside the TOPS Study

Meet the Expert Panel

SIMON ST LEDGER

Moderator CEO, Rapid Nutrition

30+ years in health and wellness, dedicated to helping people achieve better health through nutrition and lifestyle.

DR. DAVID HUNTER

Professor of Medicine and Chair of Rheumatology, University of Sydney

Ranked #1 osteoarthritis expert globally by Expertscape, with 700+ peer-reviewed publications.

DR. STEVE MESSIER

Professor and Director, JB Snow Biomechanics Lab, Wake Forest University

Principal Investigator of the NIH-funded TOPS Study, with 30+ years of clinical research in weight loss, mobility, and knee osteoarthritis.

DR. SHANNON MIHALKO

Professor of Health & Exercise Science, Wake Forest University

Specialist in behaviour change, motivation, and long-term weight maintenance.

EMILY & MONICA, TOPS Study Interventionists

Exercise Research Coordinator, Wake Forest University

Working directly with participants to support daily habits, confidence, and sustainable lifestyle change.

Channel 9 News Feature & Study Segment

Mainstream media coverage exploring the goals, broader impact, and significance of the TOPS Study.

US Study Location & Participant Overview

A behind-the-scenes look at the study sites and the people helping bring the TOPS study to life.

Want to Try the Protein Products Used in the Study?

SystemLS protein formulations are being used within the TOPS Study as part of the broader nutrition framework supporting participants throughout the program.

Designed for real life, SystemLS protein helps support satiety, fibre intake, and daily nutrition consistency — simple tools that can make healthier routines easier to maintain.

EXPLORE SYSTEMLS PROTEIN

The TOPS Study is an independent clinical research study. SystemLS nutrition products are used within the study as part of the nutrition plan. This content is for general information only and does not constitute medical advice.